Best Hotels in Cape Girardeau, Missouri

We checked thousands of reviews on and to find the best hotels for your stay
Go to Hotel List View map

Katerina Kore

Updated: 06 March 2024 · 5 min

Nestled along the western banks of the mighty Mississippi River, Cape Girardeau presents a charming blend of history, art, and natural beauty, beckoning travelers from near and far. This quaint city, with its picturesque downtown, historic landmarks, and vibrant cultural scene, offers an array of experiences that effortlessly combines relaxation with adventure. Amidst this scenic backdrop, the hotels in Cape Girardeau Missouri cater to every traveler's desire, making the city not just a destination to visit but a place to savour and indulge in.

The accommodations in Cape Girardeau vary from luxurious establishments to cozy, budget-friendly options, ensuring that every visitor finds their perfect stay. Each hotel, with its unique charm and array of amenities, strives to enhance your visit, whether you're in town for business, a romantic getaway, or a family vacation. Expert recommendations often highlight the unparalleled hospitality found at these establishments, suggesting that where you stay is integral to your overall experience of Cape Girardeau.

For those planning a trip to this beautiful part of Missouri, delving into the diverse hotel options is essential. From riverside views that captivate the serene essence of the Mississippi River to centrally located retreats within walking distance of the city’s most famed attractions, there’s a story behind every doorway. These hotels not only offer a place to rest but also serve as gateways to exploring what Cape Girardeau has in store, making them a critical component of your travel itinerary.
Show more + Show less -

Our Top 10

(Sorted by rating & number of reviews)

1. Pear Tree Inn Cape Girardeau Medical Center
2. Town House Inn Cape Girardeau
3. Drury Inn & Suites Cape Girardeau
4. Hampton Inn Cape Girardeau I-55 East, Mo
5. Quality Inn
6. Holiday Inn Express Hotel & Suites Cape Girardeau I-55, An Ihg Hotel
7. Drury Plaza Hotel Cape Girardeau Conference Center
8. Auburn Place Hotel & Suites Cape Girardeau
9. Courtyard By Marriott Cape Girardeau Downtown Hotel
10. Courtyard By Marriott Cape Girardeau Downtown Hotel

Luxury and Comfort: Top-Picked Hotels in Cape Girardeau, Missouri

Check Availability

Cape Girardeau
Mar 23, 2026 - Mar 24, 2026

Pear Tree Inn Cape Girardeau Medical Center

8.4

Good

(845 Reviews)

+ 28 photos
The Pear Tree Inn Cape Girardeau Medical Center is a testament to the fact that affordability does not compromise quality. This hotel offers clean, well-appointed rooms and a host of complimentary amenities, including breakfast, Wi-Fi, and parking. Its close proximity to the Medical Center makes it an ideal choice for visitors seeking convenience and value. The Pear Tree Inn stands out among budget-friendly hotels in Cape Girardeau as it provides a comfortable and welcoming stay for all guests, ensuring that every traveler has access to quality accommodations at an affordable price.
Address: 3248 William Street
Rating: Good 8.4 (845 Reviews)
Rooms: 78
Price: From 75$

Town House Inn Cape Girardeau

5.3

Good

(93 Reviews)

+ -1 photos
Rounding out the list of budget-friendly hotels in Cape Girardeau is the Town House Inn Cape Girardeau, a beacon of comfort and value. Guests are welcomed into a friendly atmosphere where they are treated with cordiality and respect. The hotel features modest, clean rooms, free Wi-Fi, and ample parking, ensuring a hassle-free stay. The Town House Inn proves that cost-effective lodging doesn’t have to sacrifice comfort or convenience, making it a wise choice for travelers wanting to maximize their stay while keeping expenditure to a minimum.
Address: 505 North Kingshighway Street
Rating: Good 5.3 (93 Reviews)
Rooms: 38
Price: From 70$

Budget-Friendly Stays: Affordable Hotels in Cape Girardeau, Missouri

Exploring Cape Girardeau doesn’t have to come with a hefty price tag. This section highlights hotels in Cape Girardeau that offer comfort, convenience, and value, making them perfect for travelers on a budget. From family vacations to solo adventures, these hotels provide affordable options without compromising on quality or service. Guests can expect clean, comfortable rooms, friendly service, and amenities designed to make their stay enjoyable. These selections prove that budget-friendly can also mean memorable and comfortable, offering an ideal base to explore all that Cape Girardeau has to offer.

Drury Inn & Suites Cape Girardeau

8.9

Good

(371 Reviews)

+ 77 photos
Drury Inn & Suites Cape Girardeau offers a welcoming environment for families exploring the charm of Cape Girardeau. This hotel is renowned for its spacious rooms equipped with comfortable bedding and modern conveniences to cater to the needs of both children and adults. The indoor pool and hot tub are perfect for family relaxation after a day of sightseeing. With a complimentary breakfast and evening snacks, Drury Inn & Suites ensures that every family member starts and ends their day on a high note. Their commitment to providing exceptional service makes it a top pick for families seeking memorable hotels in Cape Girardeau .
Address: 3303 Campster Drive
Rating: Good 8.9 (371 Reviews)
Rooms: 42
Price: From 73$

Hampton Inn Cape Girardeau I-55 East, Mo

9.2

Good

(242 Reviews)

+ 97 photos
The Hampton Inn Cape Girardeau I-55 East is another excellent choice for families. Situated conveniently near many of Cape Girardeau’s attractions, this hotel provides cozy accommodations with an array of amenities designed for family enjoyment. The complimentary breakfast, Wi-Fi, and clean, comfortable rooms make it easy for families to relax and recharge. An indoor pool offers entertainment for kids, ensuring that even a day in is an adventure. For families looking for a seamless and enjoyable stay, the Hampton Inn Cape Girardeau is an ideal home base.
Address: 207 S. Mount Auburn Rd.
Rating: Good 9.2 (242 Reviews)
Rooms: 86
Price: From 133$

Family-Friendly Retreats: Best Hotels in Cape Girardeau, Missouri for Families

Traveling with family requires accommodations that not only meet the standard of comfort but also provide amenities catered specifically towards both children and adults. This section highlights hotels in Cape Girardeau that stand out for their family-friendly atmosphere, services, and amenities, ensuring a pleasant and convenient stay for guests of all ages. From pools and recreational facilities to rooms that accommodate family-sized groups, these hotels go above and beyond to make sure your family feels at home.

Quality Inn

7.4

Good

(192 Reviews)

+ 52 photos
Quality Inn offers travelers a dependable and economical lodging option in the very heart of Cape Girardeau. Boasting comfortable rooms, a complimentary breakfast, and an outdoor pool, this hotel ensures a pleasant and value-packed stay. Whether you're in town for business or pleasure, Quality Inn caters to your needs, providing a home away from home without stretching your budget. This hotel eloquently combines convenience and affordability, making it a compelling choice for budget-conscious travelers seeking quality accommodations in Cape Girardeau .
Address: 2011 N. Kingshighway St.
Rating: Good 7.4 (192 Reviews)
Rooms: 49
Price: From 109$

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, An Ihg Hotel

8.8

Good

(334 Reviews)

+ 60 photos
The Holiday Inn Express Hotel & Suites Cape Girardeau I-55 provides a perfect blend of convenience and functionality for business travelers. With a 24-hour business center, meeting facilities, and free high-speed internet, guests can maintain their work momentum with ease. The hotel’s strategic location offers quick access to local businesses and attractions, making commutes effortless. With comfortable rooms designed for relaxation and work, business travelers find a balanced environment to meet their needs at the Holiday Inn Express Hotel & Suites.
Address: 3253 William Street
Rating: Good 8.8 (334 Reviews)
Rooms: 102
Price: From 144$

Business-Ready Hotels: Premier Accommodations in Cape Girardeau, Missouri for Business Travelers

For business travelers, the necessities extend beyond relaxation, requiring seamless connectivity, convenient locations, and facilities that support productivity. Highlighted in this section are hotels in Cape Girardeau that provide outstanding amenities suited for business endeavors. From high-speed internet access and workspaces in rooms to meeting and conference facilities, these hotels cater to the unique needs of the business traveler.

Drury Plaza Hotel Cape Girardeau Conference Center

9.3

Good

(421 Reviews)

+ 52 photos
Nestled at the heart of Cape Girardeau, the Drury Plaza Hotel Cape Girardeau Conference Center epitomizes elegance and convenience, making it a standout among hotels in Cape Girardeau its prime location, guests have easy access to local attractions while enjoying upscale accommodations that cater to both leisure and business travelers. The hotel boasts spacious rooms, a complimentary breakfast and evening snacks, indoor and outdoor pools, and state-of-the-art conference facilities. Its attentive staff ensures that every guest’s needs are promptly met, thereby setting the standard for Missouri hospitality. The Drury Plaza Hotel doesn’t just offer a place to stay; it promises an experience that will make your visit to Cape Girardeau truly remarkable.
Address: 3351 Percy Drive
Rating: Good 9.3 (421 Reviews)
Rooms: 238
Price: From 115$

Auburn Place Hotel & Suites Cape Girardeau

8.3

Good

(830 Reviews)

+ 45 photos
Offering a blend of cozy ambience and top-notch amenities, Auburn Place Hotel & Suites stands as a premium choice for travelers seeking comfort and quality in Cape Girardeau are greeted with warm, spacious rooms that cater to both short-term and extended stays. The hotel features an indoor pool, a fitness center, and a complimentary hot breakfast, ensuring that every aspect of your stay is catered to. Auburn Place’s friendly staff and homely atmosphere make it more than just a place to rest; it’s a place where memories are made and guests are treated like family.
Address: 3265 William Street
Rating: Good 8.3 (830 Reviews)
Rooms: 103
Price: From 69$

Courtyard By Marriott Cape Girardeau Downtown Hotel

9.0

Good

(182 Reviews)

+ 20 photos
The Courtyard By Marriott Cape Girardeau Downtown excels in catering to business travelers. Apart from its advantageous downtown location, the hotel offers free high-speed internet, a full-service business center, and versatile meeting spaces. The rooms are designed with the working guest in mind, featuring ergonomic workstations and plush seating. The on-site bistro provides healthy, delicious dining options for on-the-go professionals. The Courtyard By Marriott ensures that business travelers have everything they need for a productive and comfortable stay.
Address: 400 Broadway Street
Rating: Good 9.0 (182 Reviews)
Rooms: 91
Price: From 124$

Courtyard By Marriott Cape Girardeau Downtown Hotel

9.0

Good

(182 Reviews)

+ 20 photos
The Courtyard By Marriott Cape Girardeau Downtown combines modern amenities with impeccable service, creating a sophisticated retreat within the vibrant Cape Girardeau landscape. This hotel not only serves as a gateway to the city’s bustling downtown area but also offers a tranquil escape with its beautifully appointed rooms and suites, state-of-the-art fitness center, and on-site dining options. Guests can enjoy the elegantly designed lobby or take a breather in the serene outdoor courtyard. The Courtyard By Marriott goes beyond expectations to provide a refined and unforgettable stay, making it a distinguished choice for those seeking quality accommodations in Cape Girardeau .
Address: 400 Broadway Street
Rating: Good 9.0 (182 Reviews)
Rooms: 91
Price: From 124$